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KMID : 0624620130460030139
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BMB Reports
2013 Volume.46 No. 3 p.139 ~ p.150
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ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis
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Przemyslaw Leszczynski
Boguslaw Hendrich Andrzej
Elzbieta Szmida
Malgorzata Sasiadek Maria
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Abstract
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The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secretedproteins, while ADAMTS family only contains secreted forms. Adamalysins play an important rolein the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.
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KEYWORD
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ADAM, ADAMTS, Apoptosis, Cell proliferation, Colorectal cancer
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